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Molecular Basis of Calcium-Sensitizing and Desensitizing Mutations of the Human Cardiac Troponin C Regulatory Domain: A Multi-Scale Simulation Study

Troponin C (TnC) is implicated in the initiation of myocyte contraction via binding of cytosolic [Image: see text] and subsequent recognition of the Troponin I switch peptide. Mutations of the cardiac TnC N-terminal regulatory domain have been shown to alter both calcium binding and myofilament forc...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Kekenes-Huskey, Peter Michael, Lindert, Steffen, McCammon, James Andrew
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2012
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3510055/
https://ncbi.nlm.nih.gov/pubmed/23209387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1002777
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