Zcchc11 Uridylates Mature miRNAs to Enhance Neonatal IGF-1 Expression, Growth, and Survival

The Zcchc11 enzyme is implicated in microRNA (miRNA) regulation. It can uridylate let-7 precursors to decrease quantities of the mature miRNA in embryonic stem cell lines, suggested to mediate stem cell maintenance. It can uridylate mature miR-26 to relieve silencing activity without impacting miRNA...

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Bibliografiske detaljer
Main Authors: Jones, Matthew R., Blahna, Matthew T., Kozlowski, Elyse, Matsuura, Kori Y., Ferrari, Joseph D., Morris, Samantha A., Powers, John T., Daley, George Q., Quinton, Lee J., Mizgerd, Joseph P.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3510031/
https://ncbi.nlm.nih.gov/pubmed/23209448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003105
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