Pharmacokinetics of the estrogen receptor subtype-selective ligands, PPT and DPN: Quantification using UPLC-ES/MS/MS

Estrogen receptor (ER) subtype specific agonists, diarylpropionitrile (DPN) for ERβ and propylpyrazoletriol (PPT) for ERα, are pharmacological probes used frequently to define mechanisms for estrogen actions in vitro and in vivo. Quantitative analytical methodology was developed and validated for DP...

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Main Authors: Sepehr, Estatira, Lebl-Rinnova, Marketa, Mann, Meagan K., Pisani, Samantha L., Churchwell, Mona I., Korol, Donna L., Katzenellenbogen, John A., Doerge, Daniel R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3509942/
https://ncbi.nlm.nih.gov/pubmed/22981216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpba.2012.08.022
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