Comparison of Life-Stage-Dependent Internal Dosimetry for Bisphenol A, Ethinyl Estradiol, a Reference Estrogen, and Endogenous Estradiol to Test an Estrogenic Mode of Action in Sprague Dawley Rats

Bisphenol A (BPA) was administered by gavage (2.5–300,000 μg/kg body weight (bw)/day) to pregnant Sprague Dawley dams, newborn pups, and continuing into adulthood. Aglycone (i.e., unconjugated and active) and conjugated (i.e., inactive) BPA were evaluated by liquid chromatography electrospray tandem...

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Detalhes bibliográficos
Main Authors: Churchwell, Mona I., Camacho, Luísa, Vanlandingham, Michelle M., Twaddle, Nathan C., Sepehr, Estatira, Delclos, K. Barry, Fisher, Jeffrey W., Doerge, Daniel R.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
Assuntos:
Biotransformation and Toxicokinetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4038784/
https://ncbi.nlm.nih.gov/pubmed/24496641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfu021
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