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Virtual Screening and Optimization Yield Low-Nanomolar Inhibitors of the Tautomerase Activity of Plasmodium falciparum Macrophage Migration Inhibitory Factor
The Plasmodium falciparum ortholog of the human cytokine, macrophage migratory inhibitory factor (PfMIF), is produced by the parasite during malaria infection and modulates the host’s immune response. As for other MIF orthologs, PfMIF has tautomerase activity, whose inhibition may influence the cyto...
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| Autors principals: | , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3509768/ https://ncbi.nlm.nih.gov/pubmed/23067344 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm301269s |
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