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Endothelial deletion of murine Jag1 leads to valve calcification and congenital heart defects associated with Alagille syndrome

The Notch signaling pathway is an important contributor to the development and homeostasis of the cardiovascular system. Not surprisingly, mutations in Notch receptors and ligands have been linked to a variety of hereditary diseases that impact both the heart and the vasculature. In particular, muta...

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Bibliografiset tiedot
Päätekijät: Hofmann, Jennifer J., Briot, Anais, Enciso, Josephine, Zovein, Ann C., Ren, Shuxun, Zhang, Zhen W., Radtke, Freddy, Simons, Michael, Wang, Yibin, Iruela-Arispe, M. Luisa
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Company of Biologists 2012
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3509736/
https://ncbi.nlm.nih.gov/pubmed/23095891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.084871
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