Jagged1 in the portal vein mesenchyme regulates intrahepatic bile duct development: insights into Alagille syndrome

Mutations in the human Notch ligand jagged 1 (JAG1) result in a multi-system disorder called Alagille syndrome (AGS). AGS is chiefly characterized by a paucity of intrahepatic bile ducts (IHBD), but also includes cardiac, ocular, skeletal, craniofacial and renal defects. The disease penetration and...

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Dettagli Bibliografici
Autori principali: Hofmann, Jennifer J., Zovein, Ann C., Koh, Huilin, Radtke, Freddy, Weinmaster, Gerry, Iruela-Arispe, M. Luisa
Natura: Artigo
Lingua:Inglês
Pubblicazione: Company of Biologists 2010
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2976287/
https://ncbi.nlm.nih.gov/pubmed/21062863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.052118
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