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The −258 A/G (SNP rs12885300) polymorphism of the human type-2 deiodinase gene is associated with a shift in the pattern of secretion of thyroid hormones following a TRH-induced acute rise in TSH

OBJECTIVE: Type-2 deiodinase gene (DIO2) polymorphisms have been associated with changes in pituitary-thyroid axis homeostasis. The −258 A/G (SNP rs12885300) polymorphism has been associated with increased enzymatic activity, but data are conflicting. To characterize the effects of the −258 A/G poly...

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Detalhes bibliográficos
Main Authors: Peltsverger, Maya Y., Butler, Peter W., Alberobello, Anna Teresa, Smith, Sheila, Guevara, Yanina, Dubaz, Ornella M., Luzon, Javier A., Linderman, Joyce, Celi, Francesco S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3509195/
https://ncbi.nlm.nih.gov/pubmed/22307573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/EJE-11-1073
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