The Thr92Ala 5′ Type 2 Deiodinase Gene Polymorphism Is Associated with a Delayed Triiodothyronine Secretion in Response to the Thyrotropin-Releasing Hormone–Stimulation Test: A Pharmacogenomic Study

BACKGROUND: The common Thr92Ala D2 polymorphism has been associated with changes in pituitary–thyroid axis homeostasis, but published results are conflicting. To investigate the effects of the Thr92Ala polymorphism on intrathyroidal thyroxine (T4) to triiodothyronine (T3) conversion, we designed pro...

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Bibliographische Detailangaben
Hauptverfasser: Butler, Peter W., Smith, Sheila M., Linderman, Joyce D., Brychta, Robert J., Alberobello, Anna Teresa, Dubaz, Ornella M., Luzon, Javier A., Skarulis, Monica C., Cochran, Craig S., Wesley, Robert A., Pucino, Frank, Celi, Francesco Saverio
Format: Artigo
Sprache:Inglês
Veröffentlicht: Mary Ann Liebert, Inc. 2010
Schlagworte:
Original Studies, Reviews, and Scholarly Dialog
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2990280/
https://ncbi.nlm.nih.gov/pubmed/21054208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/thy.2010.0244
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