The Thr92Ala 5′ Type 2 Deiodinase Gene Polymorphism Is Associated with a Delayed Triiodothyronine Secretion in Response to the Thyrotropin-Releasing Hormone–Stimulation Test: A Pharmacogenomic Study

BACKGROUND: The common Thr92Ala D2 polymorphism has been associated with changes in pituitary–thyroid axis homeostasis, but published results are conflicting. To investigate the effects of the Thr92Ala polymorphism on intrathyroidal thyroxine (T4) to triiodothyronine (T3) conversion, we designed pro...

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Detalhes bibliográficos
Main Authors: Butler, Peter W., Smith, Sheila M., Linderman, Joyce D., Brychta, Robert J., Alberobello, Anna Teresa, Dubaz, Ornella M., Luzon, Javier A., Skarulis, Monica C., Cochran, Craig S., Wesley, Robert A., Pucino, Frank, Celi, Francesco Saverio
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2010
Assuntos:
Original Studies, Reviews, and Scholarly Dialog
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2990280/
https://ncbi.nlm.nih.gov/pubmed/21054208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/thy.2010.0244
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