The Thr92Ala 5′ Type 2 Deiodinase Gene Polymorphism Is Associated with a Delayed Triiodothyronine Secretion in Response to the Thyrotropin-Releasing Hormone–Stimulation Test: A Pharmacogenomic Study

BACKGROUND: The common Thr92Ala D2 polymorphism has been associated with changes in pituitary–thyroid axis homeostasis, but published results are conflicting. To investigate the effects of the Thr92Ala polymorphism on intrathyroidal thyroxine (T4) to triiodothyronine (T3) conversion, we designed pro...

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Main Authors: Butler, Peter W., Smith, Sheila M., Linderman, Joyce D., Brychta, Robert J., Alberobello, Anna Teresa, Dubaz, Ornella M., Luzon, Javier A., Skarulis, Monica C., Cochran, Craig S., Wesley, Robert A., Pucino, Frank, Celi, Francesco Saverio
Formato: Artigo
Idioma:Inglês
Publicado: Mary Ann Liebert, Inc. 2010
Assuntos:
Original Studies, Reviews, and Scholarly Dialog
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2990280/
https://ncbi.nlm.nih.gov/pubmed/21054208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/thy.2010.0244
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