Thyroxine-induced induction of pyroglutamyl peptidase II and inhibition of TSH release precedes suppression of TRH mRNA and requires type 2 deiodinase

Suppression of TSH release from the hypothyroid thyrotrophs is one of the most rapid effects of T3 or T4. It is initiated within an hour, and precedes the decrease in TSHβ mRNA inhibition and is blocked by inhibitors of mRNA or protein synthesis. TSH elevation in primary hypothyroidism requires both...

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Auteurs principaux: Marsili, Alessandro, Sanchez, Edith, Singru, Praful, Harney, John W., Zavacki, Ann Marie, Lechan, Ronald M., Larsen, P. Reed
Format: Artigo
Langue:Inglês
Publié: 2011
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3558748/
https://ncbi.nlm.nih.gov/pubmed/21788297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/JOE-11-0248
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