MUTATIONS AND POLYMORPHISMS IN HEMOGLOBIN GENES AND THE RISK OF PULMONARY HYPERTENSION AND DEATH IN SICKLE CELL DISEASE

Pulmonary hypertension is a common complication of sickle cell disease (SCD) and a risk factor for early death. Hemolysis may participate in its pathogenesis by limiting nitric oxide (NO) bioavailability and producing vasculopathy. We hypothesized that hemoglobin mutations that diminish hemolysis in...

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Detalhes bibliográficos
Main Authors: Taylor, James G., Ackah, Diana, Cobb, Crystal, Orr, Nick, Percy, Melanie J., Sachdev, Vandana, Machado, Roberto, Castro, Oswaldo, Kato, Gregory J., Chanock, Stephen J., Gladwin, Mark T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3509176/
https://ncbi.nlm.nih.gov/pubmed/17724704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ajh.21035
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