Endothelin receptor antagonists for pulmonary hypertension in adult patients with sickle cell disease

Pulmonary Hypertension is a serious complication of sickle cell disease (SCD), with a high risk of morbidity and mortality. Endothelin-1, a potent vasoconstrictor peptide known to be elevated in SCD, acts through two receptors: ETR-A and ETR-B. Bosentan and ambrisentan are ETR blockers approved for...

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Hauptverfasser: Minniti, Caterina P, Machado, Roberto F, Coles, Wynona A, Sachdev, Vandana, Gladwin, Mark T, Kato, Gregory J
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3225273/
https://ncbi.nlm.nih.gov/pubmed/19775299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2141.2009.07906.x
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