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Chemically engineering ligand selectivity at the free fatty acid receptor 2 based on pharmacological variation between species orthologs
When it is difficult to develop selective ligands within a family of related G-protein-coupled receptors (GPCRs), chemically engineered receptors activated solely by synthetic ligands (RASSLs) are useful alternatives for probing receptor function. In the present work, we explored whether a RASSL of...
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| Autores principales: | , , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Federation of American Societies for Experimental Biology
2012
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3509056/ https://ncbi.nlm.nih.gov/pubmed/22919070 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.12-213314 |
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