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Thermodynamics and kinetics of the hairpin ribozyme from atomistic folding/unfolding simulations
We report a set of atomistic folding/unfolding simulations for the hairpin ribozyme using a monte carlo algorithm. The hairpin ribozyme folds in solution and catalyzes self-cleavage or ligation via a specific two-domain structure. The minimal active ribozyme has been studied extensively, showing sta...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2011
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3508787/ https://ncbi.nlm.nih.gov/pubmed/21740912 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.06.042 |
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