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Molecular and functional determinants of local anesthetic inhibition of NaChBac

In our recent publication, we describe the local anesthetic (LA) inhibition of the prokaryotic voltage gated sodium channel NaChBac. Despite the numerous functional and putative structural differences with the mammalian sodium channels, the data show that LA compounds effectively and reversibly inhi...

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Bibliografische gegevens
Hoofdauteurs: Lee, Sora, Goodchild, Samuel J., Ahern, Christopher A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Landes Bioscience 2012
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3508782/
https://ncbi.nlm.nih.gov/pubmed/22992485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/chan.21807
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