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The spliceosome: a flexible, reversible macromolecular machine
With more than a hundred individual RNA and protein parts and a highly dynamic assembly and disassembly pathway, the spliceosome is arguably the most complicated macromolecular machine in the eukaryotic cell. This complexity has made kinetic and mechanistic analysis of splicing incredibly challengin...
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| Autores principales: | , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3508674/ https://ncbi.nlm.nih.gov/pubmed/22480731 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tibs.2012.02.009 |
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