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Chronic Inhibition of Dopamine β-Hydroxylase Facilitates Behavioral Responses to Cocaine in Mice

The anti-alcoholism medication, disulfiram (Antabuse), decreases cocaine use in humans regardless of concurrent alcohol consumption and facilitates cocaine sensitization in rats, but the functional targets are unknown. Disulfiram inhibits dopamine β-hydroxylase (DBH), the enzyme that converts dopami...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Gaval-Cruz, Meriem, Liles, Larry Cameron, Iuvone, Paul Michael, Weinshenker, David
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3507785/
https://ncbi.nlm.nih.gov/pubmed/23209785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0050583
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