The Mechanism of Prion Inhibition by HET-S

HET-S (97% identical to HET-s) has an N-terminal globular domain that exerts a prion-inhibitory effect in cis on its own prion-forming domain (PFD) and in trans on HET-s prion propagation. We show that HET-S fails to form fibrils in vitro and that it inhibits HET-s PFD fibrillization in trans. In vi...

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Detalhes bibliográficos
Main Authors: Greenwald, Jason, Buhtz, Carolin, Ritter, Christiane, Kwiatkowski, Witek, Choe, Senyon, Maddelein, Marie-Lise, Ness, Frederique, Cescau, Sandra, Soragni, Alice, Leitz, Dominik, Saupe, Sven J., Riek, Roland
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3507513/
https://ncbi.nlm.nih.gov/pubmed/20620958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2010.05.019
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