A non Q/N-rich prion domain of a foreign prion, [Het-s], can propagate as a prion in yeast

Prions are self-propagating, infectious aggregates of misfolded proteins. The mammalian prion, PrP(Sc), causes fatal neurodegenerative disorders. Fungi also have prions. While yeast prions depend upon glutamine/asparagine(Q/N)-rich regions, the Podospora anserina HET-s and PrP prion proteins, lack s...

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Autores principales: Taneja, Vibha, Maddelein, Marie-Lise, Talarek, Nicolas, J. Saupe, Sven, Liebman, Susan W.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2007
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1995001/
https://ncbi.nlm.nih.gov/pubmed/17612491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2007.05.027
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