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A non Q/N-rich prion domain of a foreign prion, [Het-s], can propagate as a prion in yeast
Prions are self-propagating, infectious aggregates of misfolded proteins. The mammalian prion, PrP(Sc), causes fatal neurodegenerative disorders. Fungi also have prions. While yeast prions depend upon glutamine/asparagine(Q/N)-rich regions, the Podospora anserina HET-s and PrP prion proteins, lack s...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1995001/ https://ncbi.nlm.nih.gov/pubmed/17612491 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2007.05.027 |
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