Correlation of structure and infectivity of the HET-s prion

Prions are believed to be infectious self-propagating polymers of otherwise soluble host-encoded proteins1,2. This concept is now strongly supported by the recent findings that amyloid fibrils of recombinant prion proteins from yeast3-5, Podospora anserina6, and mammals7 can induce prion phenotypes...

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Bibliografiske detaljer
Main Authors: Ritter, Christiane, Maddelein, Marie-Lise, Siemer, Ansgar B., Lührs, Thorsten, Ernst, Matthias, Meier, Beat H., Saupe, Sven, Riek, Roland
Format: Artigo
Sprog:Inglês
Udgivet: 2005
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1567094/
https://ncbi.nlm.nih.gov/pubmed/15944710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature03793
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