Calsyntenin-1 shelters APP from proteolytic processing during anterograde axonal transport

Endocytosis of amyloid-β precursor protein (APP) is thought to represent the major source of substrate for the production of the amyloidogenic Aβ peptide by the β-secretase BACE1. The irreversible nature of proteolytic cleavage implies the existence of an efficient replenishment route for APP from i...

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Detalles Bibliográficos
Main Authors: Steuble, Martin, Diep, Tu-My, Schätzle, Philipp, Ludwig, Alexander, Tagaya, Mitsuo, Kunz, Beat, Sonderegger, Peter
Formato: Artigo
Idioma:Inglês
Publicado: The Company of Biologists 2012
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3507217/
https://ncbi.nlm.nih.gov/pubmed/23213470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/bio.20121578
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