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Protracted low doses of temozolomide for the treatment of patients with recurrent glioblastoma: A phase II study
O(6)-alkylguanine-DNA alkyltransferase (AGAT), involved in temozolomide-induced DNA damage repair, plays a key role in the efficacy of temozolomide. AGAT activity may be reduced by protracted temozolomide doses. On the basis of the preclinical findings, we treated patients with a histologically-prov...
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| Glavni autori: | , , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
D.A. Spandidos
2012
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3506588/ https://ncbi.nlm.nih.gov/pubmed/23205103 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ol.2012.788 |
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