Protracted low doses of temozolomide for the treatment of patients with recurrent glioblastoma: A phase II study

O(6)-alkylguanine-DNA alkyltransferase (AGAT), involved in temozolomide-induced DNA damage repair, plays a key role in the efficacy of temozolomide. AGAT activity may be reduced by protracted temozolomide doses. On the basis of the preclinical findings, we treated patients with a histologically-prov...

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Hoofdauteurs: SANTONI, MATTEO, PACCAPELO, ALESSANDRO, BURATTINI, LUCIANO, BIANCONI, MARISTELLA, CARDINALI, MASSIMO, FABBIETTI, LETIZIA, TRIGNANI, ROBERTO, RYCHLICKI, FRANCO, CASCINU, STEFANO
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: D.A. Spandidos 2012
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Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3506588/
https://ncbi.nlm.nih.gov/pubmed/23205103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ol.2012.788
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