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Learning from Decoys to Improve the Sensitivity and Specificity of Proteomics Database Search Results
The statistical validation of database search results is a complex issue in bottom-up proteomics. The correct and incorrect peptide spectrum match (PSM) scores overlap significantly, making an accurate assessment of true peptide matches challenging. Since the complete separation between the true and...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2012
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3506577/ https://ncbi.nlm.nih.gov/pubmed/23189209 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0050651 |
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