Genetic Targeting Aromatase in Male Amyloid Precursor Protein Transgenic Mice Down-Regulates β-Secretase (BACE1) and Prevents Alzheimer-Like Pathology and Cognitive Impairment

As brain testosterone plays both androgenic and estrogenic actions due to its conversion into estrogen via aromatase naturally, it is unclear that the age-related reduction of testosterone increased risk of Alzheimer's disease (AD) in men is mediated through androgen alone or both androgen and...

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Auteurs principaux: McAllister, Carrie, Long, Jiangang, Bowers, Adrienne, Walker, Aaron, Cao, Philip, Honda, Shin-Ichiro, Harada, Nobuhiro, Staufenbiel, Matthias, Shen, Yong, Li, Rena
Format: Artigo
Langue:Inglês
Publié: Society for Neuroscience 2010
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3506430/
https://ncbi.nlm.nih.gov/pubmed/20505099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1180-10.2010
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