Time-resolved FRET between GPCR ligands reveals oligomers in native tissues

G protein–coupled receptor (GPCR) oligomers have been proposed to play critical roles in cell signaling, but confirmation of their existence in a native context remains elusive, as no direct interactions between receptors have been reported. To demonstrate their presence in native tissues, we develo...

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Autors principals: Albizu, Laura, Cottet, Martin, Kralikova, Michaela, Stoev, Stoytcho, Seyer, René, Brabet, Isabelle, Roux, Thomas, Bazin, Hervé, Bourrier, Emmanuel, Lamarque, Laurent, Breton, Christophe, Rives, Marie-Laure, Newman, Amy, Javitch, Jonathan, Trinquet, Eric, Manning, Maurice, Pin, Jean-Philippe, Mouillac, Bernard, Durroux, Thierry
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3506176/
https://ncbi.nlm.nih.gov/pubmed/20622858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.396
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