Interleukin-6 Production in CD40-Engaged Fibrocytes in Thyroid-Associated Ophthalmopathy: Involvement of Akt and NF-κB

PURPOSE. CD40–CD40 ligand (CD40L) interactions appear to play pathogenic roles in autoimmune disease. Here we quantify CD40 expression on fibrocytes, circulating, and bone marrow–derived progenitor cells. The functional consequences of CD40 ligation are determined since these may promote tissue remo...

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Main Authors: Gillespie, Erin F., Raychaudhuri, Nupur, Papageorgiou, Konstantinos I., Atkins, Stephen J., Lu, Ying, Charara, Laya K., Mester, Tünde, Smith, Terry J., Douglas, Raymond S.
Format: Artigo
Language:Inglês
Published: The Association for Research in Vision and Ophthalmology 2012
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3506052/
https://ncbi.nlm.nih.gov/pubmed/23092922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.12-9861
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