Nf1 mutant mice with p19ARF gene loss develop accelerated hematopoietic disease resembling acute leukemia with a variable phenotype

Juvenile Myelomonocytic Leukemia (JMML) is a relentlessly progressive myeloproliferative/myelodysplastic (MPD/MDS) hematopoietic disorder more common in patients with any one of at least three distinct genetic lesions, specifically NF1 gene loss and PTPN11 and NRAS mutations. NF1 and PTPN11 are mole...

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Main Authors: Wiesner, Stephen M., Geurts, Jennifer L., Diers, Miechaleen D., Bergerson, Rachel J., Hasz, Diane E., Morgan, Kelly J., Largaespada, David A.
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3506005/
https://ncbi.nlm.nih.gov/pubmed/21681782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ajh.22035
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