The SMAD2/3 corepressor SNON maintains pluripotency through selective repression of mesendodermal genes in human ES cells

Activin/Nodal signaling via SMAD2/3 maintains human embryonic stem cell (hESC) pluripotency by direct transcriptional regulation of NANOG or, alternatively, induces mesoderm and definitive endoderm (DE) formation. In search of an explanation for these contrasting effects, we focused on SNON (SKIL),...

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Detalhes bibliográficos
Main Authors: Tsuneyoshi, Norihiro, Tan, Ee Kim, Sadasivam, Akila, Poobalan, Yogavalli, Sumi, Tomoyuki, Nakatsuji, Norio, Suemori, Hirofumi, Dunn, N. Ray
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2012
Assuntos:
Research Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3505817/
https://ncbi.nlm.nih.gov/pubmed/23154981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.201772.112
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