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Spliceosome activation: U4 is the path, stem I is the goal, and Prp8 is the keeper. Let's cheer for the ATPase Brr2!
During pre-mRNA splicing, the spliceosome is activated for catalysis by unwinding base-paired U4/U6 small nuclear RNAs, a step that must be precisely timed. We know that unwinding requires the ATPase Brr2, but the mechanism and regulation of unwinding have been understood poorly. In the November 1,...
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| Main Authors: | , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Cold Spring Harbor Laboratory Press
2012
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| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3505815/ https://ncbi.nlm.nih.gov/pubmed/23154979 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.207514.112 |
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