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Exonuclease 1 (Exo1) is required for activating response to S(N)1 DNA methylating agents
S(N)1 DNA methylating agents are genotoxic agents that methylate numerous nucleophilic centers within DNA including the O(6) position of guanine (O(6)meG). Methylation of this extracyclic oxygen forces mispairing with thymine during DNA replication. The mismatch repair (MMR) system recognizes these...
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Main Authors: | , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2012
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3505598/ https://ncbi.nlm.nih.gov/pubmed/23062884 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2012.09.004 |
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