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Exonuclease 1 (Exo1) is required for activating response to S(N)1 DNA methylating agents

S(N)1 DNA methylating agents are genotoxic agents that methylate numerous nucleophilic centers within DNA including the O(6) position of guanine (O(6)meG). Methylation of this extracyclic oxygen forces mispairing with thymine during DNA replication. The mismatch repair (MMR) system recognizes these...

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Detalhes bibliográficos
Main Authors: Izumchenko, Eugene, Saydi, John, Brown, Kevin D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3505598/
https://ncbi.nlm.nih.gov/pubmed/23062884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2012.09.004
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