Disordered purinergic signaling and abnormal cellular metabolism are associated with development of liver cancer in Cd39/Entpd1 null mice

Liver cancer is associated with chronic inflammation, which is linked to immune dysregulation, disordered metabolism and aberrant cell proliferation. CD39/ENTPD1 is an ectonucleotidase that regulates extracellular nucleotide/nucleoside concentrations by scavenging nucleotides to ultimately generate...

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Main Authors: Sun, Xiaofeng, Han, Lihui, Seth, Pankaj, Bian, Shu, Li, Linglin, Csizmadia, Eva, Junger, Wolfgang G., Schmelzle, Moritz, Usheva, Anny, Tapper, Elliot B., Baffy, Gyorgy, Sukhatme, Vikas P., Wu, Yan, Robson, Simon C.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3505255/
https://ncbi.nlm.nih.gov/pubmed/22859060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.25989
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