Design, Synthesis, Structural and Functional Characterization of Novel Melanocortin Agonists Based on the Cyclotide Kalata B1

Obesity is an increasingly important global health problem that lacks current treatment options. The melanocortin receptor 4 (MC4R) is a target for obesity therapies because its activation triggers appetite suppression and increases energy expenditure. Cyclotides have been suggested as scaffolds for...

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Autori principali: Eliasen, Rasmus, Daly, Norelle L., Wulff, Birgitte S., Andresen, Thomas L., Conde-Frieboes, Kilian W., Craik, David J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2012
Soggetti:
Protein Structure and Folding
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3504764/
https://ncbi.nlm.nih.gov/pubmed/23012369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.395442
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