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Molecular structure of an anticancer drug-DNA complex: daunomycin plus d(CpGpTpApCpG).

The structure of the crystalline daunomycin-d(CpGpTpApCpG) complex has been solved by x-ray diffraction analysis. The DNA forms a six-base-pair right-handed double helix with two daunomycin molecules intercalated in the d(CpG) sequences. The daunomycin aglycone chromophore is oriented at right angle...

Täydet tiedot

Tallennettuna:
Julkaisussa:Proc Natl Acad Sci U S A
Päätekijät: Quigley, G J, Wang, A H, Ughetto, G, van der Marel, G, van Boom, J H, Rich, A
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 1980
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC350470/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6938965/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.77.12.7204
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