Molecular structure of an anticancer drug-DNA complex: daunomycin plus d(CpGpTpApCpG).
The structure of the crystalline daunomycin-d(CpGpTpApCpG) complex has been solved by x-ray diffraction analysis. The DNA forms a six-base-pair right-handed double helix with two daunomycin molecules intercalated in the d(CpG) sequences. The daunomycin aglycone chromophore is oriented at right angle...
Shranjeno v:
| izdano v: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
1980
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC350470/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6938965/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.77.12.7204 |
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