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Differential efficacy of DOTAP enantiomers for siRNA delivery in vitro

DOTAP, as a racemic mixture, is a cationic lipid and a widely used transfection reagent. In this study, the effect of DOTAP’s stereochemical structure on transfection efficiency was evaluated in vitro. Racemic and enantiomerically pure DOTAP were used in lipoplex formulations to deliver siRNA to MCF...

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Bibliografische gegevens
Hoofdauteurs: Terp, Megan Cavanaugh, Bauer, Finn, Sugimoto, Yasuro, Yu, Bo, Brueggemeier, Robert W., Lee, L. James, Lee, Robert J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2012
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3504612/
https://ncbi.nlm.nih.gov/pubmed/22525086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijpharm.2012.04.017
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