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Differential efficacy of DOTAP enantiomers for siRNA delivery in vitro
DOTAP, as a racemic mixture, is a cationic lipid and a widely used transfection reagent. In this study, the effect of DOTAP’s stereochemical structure on transfection efficiency was evaluated in vitro. Racemic and enantiomerically pure DOTAP were used in lipoplex formulations to deliver siRNA to MCF...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3504612/ https://ncbi.nlm.nih.gov/pubmed/22525086 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijpharm.2012.04.017 |
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