A cyclic enkephalin analog with high in vitro opiate activity.
A conformationally restricted analog of [Leu5]enkephalin was synthesized by cyclization of the COOH-terminal carboxyl group of leucine to the gamma-amino moiety of alpha, gamma-diaminobutyric acid (A2bu) substituted in position 2 of the peptide. Relative to [Leu5]enkephalin, the cyclic analog with D...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
1980
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC350461/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6261242/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.77.12.7162 |
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