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A cyclic enkephalin analog with high in vitro opiate activity.

A conformationally restricted analog of [Leu5]enkephalin was synthesized by cyclization of the COOH-terminal carboxyl group of leucine to the gamma-amino moiety of alpha, gamma-diaminobutyric acid (A2bu) substituted in position 2 of the peptide. Relative to [Leu5]enkephalin, the cyclic analog with D...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: DiMaio, J, Schiller, P W
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 1980
Subjects:
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC350461/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6261242/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.77.12.7162
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