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Oncogenes in Cell Survival and Cell Death

The transforming effects of proto-oncogenes such as MYC that mediate unrestrained cell proliferation are countered by “intrinsic tumor suppressor mechanisms” that most often trigger apoptosis. Therefore, cooperating genetic or epigenetic effects to suppress apoptosis (e.g., overexpression of BCL2) a...

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Detalhes bibliográficos
Main Authors: Shortt, Jake, Johnstone, Ricky W.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3504432/
https://ncbi.nlm.nih.gov/pubmed/23209150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a009829
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