A carregar...
From Anecdote to Targeted Therapy: The Curious Case of Thalidomide in Multiple Myeloma
Thalidomide and related drugs are key drugs for the treatment of multiple myeloma (MM). These agents bind to cereblon, a component of an ubiquitin ligase complex, altering the specificity of the complex to induce the ubiquitylation and degradation of Ikaros (IKZF1) and Aiolos (IKZF3), transcription...
Na minha lista:
| Main Authors: | , , |
|---|---|
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
|
| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3984916/ https://ncbi.nlm.nih.gov/pubmed/24434206 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2013.12.019 |
| Tags: |
Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
|