Nalaganje...
From Anecdote to Targeted Therapy: The Curious Case of Thalidomide in Multiple Myeloma
Thalidomide and related drugs are key drugs for the treatment of multiple myeloma (MM). These agents bind to cereblon, a component of an ubiquitin ligase complex, altering the specificity of the complex to induce the ubiquitylation and degradation of Ikaros (IKZF1) and Aiolos (IKZF3), transcription...
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| Main Authors: | , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2014
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3984916/ https://ncbi.nlm.nih.gov/pubmed/24434206 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2013.12.019 |
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