Botulinum Neurotoxin Serotype a Specific Cell-Based Potency Assay to Replace the Mouse Bioassay

Botulinum neurotoxin serotype A (BoNT/A), a potent therapeutic used to treat various disorders, inhibits vesicular neurotransmitter exocytosis by cleaving SNAP25. Development of cell-based potency assays (CBPAs) to assess the biological function of BoNT/A have been challenging because of its potency...

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Main Authors: Fernández-Salas, Ester, Wang, Joanne, Molina, Yanira, Nelson, Jeremy B., Jacky, Birgitte P. S., Aoki, K. Roger
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3504020/
https://ncbi.nlm.nih.gov/pubmed/23185348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0049516
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