Alterations in Cellular Energy Metabolism Associated with the Antiproliferative Effects of the ATM Inhibitor KU-55933 and with Metformin

KU-55933 is a specific inhibitor of the kinase activity of the protein encoded by Ataxia telangiectasia mutated (ATM), an important tumor suppressor gene with key roles in DNA repair. Unexpectedly for an inhibitor of a tumor suppressor gene, KU-55933 reduces proliferation. In view of prior prelimina...

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Detaylı Bibliyografya
Asıl Yazarlar: Zakikhani, Mahvash, Bazile, Miguel, Hashemi, Sina, Javeshghani, Shiva, Avizonis, Daina, Pierre, Julie St, Pollak, Michael N.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2012
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3504012/
https://ncbi.nlm.nih.gov/pubmed/23185347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0049513
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