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Receptor-mediated internalization of fluorescent gonadotropin-releasing hormone by pituitary gonadotropes.

A bioactive, fluorescent derivative of gonadotropin-releasing hormone, < Glu-His-Trp-Ser-Tyr-D-Lys(N epsilon-tetramethylrhodamine)-Leu-Arg-Pro-Gly-NH2, was prepared. This peptide retained high-affinity binding (apparent dissociation constant, 3 nM) to the receptor for gonadotropin-releasing hormone...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Hazum, E, Cuatrecasas, P, Marian, J, Conn, P M
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1980
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC350354/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6256756/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.77.11.6692
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