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Membrane Association of the PTEN Tumor Suppressor: Electrostatic Interaction with Phos-phatidylserine-Containing Bilayers and Regulatory Role of the C-Terminal Tail

The phosphatidylinositolphosphate phosphatase PTEN is the second most frequently mutated protein in human tumors. Its membrane association, allosteric activation and membrane dissociation are poorly understood. We recently reported PTEN binding affinities to membranes of different compositions and a...

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Detalhes bibliográficos
Main Authors: Shenoy, Siddharth S., Nanda, Hirsh, Lösche, Mathias
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3503488/
https://ncbi.nlm.nih.gov/pubmed/23073177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsb.2012.10.003
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