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The PTEN tumor suppressor forms homodimers in solution
As the phosphoinositol-3-kinase antagonist in the PI3K pathway, the PTEN tumor suppressor exerts phosphatase activity on diacylphosphatidylinositoltriphosphate in the plasma membrane. Even partial loss of this activity enhances tumorigenesis, but a mechanistic basis for this aspect of PTEN physiolog...
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| Publicado no: | Structure |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4598300/ https://ncbi.nlm.nih.gov/pubmed/26299948 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2015.07.012 |
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