Utilization of Sialylated Glycans as Coreceptors Enhances the Neurovirulence of Serotype 3 Reovirus

Mammalian reoviruses display serotype-specific patterns of tropism and disease in the murine central nervous system (CNS) attributable to polymorphisms in viral attachment protein σ1. While all reovirus serotypes use junctional adhesion molecule-A as a cellular receptor, they differ in their utiliza...

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Detalhes bibliográficos
Main Authors: Frierson, Johnna M., Pruijssers, Andrea J., Konopka, Jennifer L., Reiter, Dirk M., Abel, Ty W., Stehle, Thilo, Dermody, Terence S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3503066/
https://ncbi.nlm.nih.gov/pubmed/23035227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01822-12
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