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The Reovirus σ1s Protein Is a Determinant of Hematogenous but Not Neural Virus Dissemination in Mice

Nonstructural protein σ1s is a critical determinant of hematogenous dissemination by type 1 reoviruses, which reach the central nervous system (CNS) by a strictly blood-borne route. However, it is not known whether σ1s contributes to neuropathogenesis of type 3 reoviruses, which disseminate by both...

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Detalhes bibliográficos
Main Authors: Boehme, Karl W., Frierson, Johnna M., Konopka, Jennifer L., Kobayashi, Takeshi, Dermody, Terence S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3209282/
https://ncbi.nlm.nih.gov/pubmed/21917967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02289-10
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