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Fe(2+) Block and Permeation of Ca(V)3.1 (α1G) T-Type Calcium Channels: Candidate Mechanism for Non–Transferrin-Mediated Fe(2+) Influx

Iron is a biologically essential metal, but excess iron can cause damage to the cardiovascular and nervous systems. We examined the effects of extracellular Fe(2+) on permeation and gating of Ca(V)3.1 channels stably transfected in HEK293 cells, by using whole-cell recording. Precautions were taken...

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מידע ביבליוגרפי
Main Authors: Lopin, Kyle V., Gray, I. Patrick, Obejero-Paz, Carlos A., Thévenod, Frank, Jones, Stephen W.
פורמט: Artigo
שפה:Inglês
יצא לאור: The American Society for Pharmacology and Experimental Therapeutics 2012
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3502628/
https://ncbi.nlm.nih.gov/pubmed/22973060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.112.080184
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